Registration Dossier
Registration Dossier
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EC number: 935-454-7 | CAS number: 68516-18-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Previously, there was a testing proposal to conduct a 90 day sub-chronic study on the structurally related substance Alkenes C11-12, hydroformylation products, dist. Residues (CAS 90622-27-8). It was proposed to read-across the results from that study to this substance.
The proposed study was, indeed, performed. Administration of the read-across substance Alkenes, C11/C12, hydroformylation products, distillation residues by once daily oral gavage was well tolerated in rats at levels of 100, 300 and 1000 mg/kg/day. Based on the results, the no-observed-effect level (NOEL) for males was considered to be 1000 mg/kg/day. Due to reversible changes in the liver weights in females the no-observed-adverse-effect level (NOAEL) was considered to be 1000 mg/kg/day. These study results, with no adverse effects at the highest dose tested (the limit dose for the study), support the expectation that Decene, hydroformylation products, high boiling would exhibit low repeated dose toxicity.
Justification for classification or non-classification
The observation of a NOAEL >1000 mg/kg/day in an augmented 90 day sub-chronic study for a structurally related substance supports the conclusion that data for the registered substance are conclusive but insufficient for classification.
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