Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 233-046-7 | CAS number: 10025-87-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Molodkina, N.N.
- Year:
- 1 984
- Bibliographic source:
- Gig. Truda Prof. Zabol. 10, 30 (1971);|cited in: MAK-Begruendung "Phosphoroxidchlorid" (1984)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Molodkina, N.N.
- Year:
- 1 984
- Bibliographic source:
- Toksikol. Nov. Prom. Khim. Veshch. 13, 107|(1973);|cited in: MAK-Begruendung "Phosphoroxidchlorid" (1984)
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- phosphorus oxychloride
- IUPAC Name:
- phosphorus oxychloride
- Details on test material:
- no data on purity of the compound
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- undiluted
other: 1 drop - Details on study design:
- Instillation of one drop (ca. 0.1 ml) of the undiluted test subtance into the conjunctival sac.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: description
- Remarks on result:
- other: irreversible necrosis and total loss of the visual power. Only secondary literature; no further data.
- Irritant / corrosive response data:
- corrosive
- Other effects:
- irreversible necrosis and total loss of the visual power. Only secondary literature; no further data.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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