Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according EU/OECD guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
Cas Number:
213265-81-7
Molecular formula:
C10H5Cl2FN2O
IUPAC Name:
4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
Radiolabelling:
no

Study design

Analytical monitoring:
no

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0 s-1
DT50:
13 900 h
pH:
7
Temp.:
50 °C
Remarks on result:
other: Within five days the degradation was less than 10%.
pH:
4
Temp.:
50 °C
Remarks on result:
other: Within five days the degradation was less than 10%.

Any other information on results incl. tables

The calculation of the half times and the reaction rate constants were based on linear regression (In c versus t and In k versus T"1 respectively) following the first order concentration-time-law.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The substance is hydrolytically not degradable at pH 7 and pH 4.
The test substance is hydrolytically degradable at pH 9.