Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well performed OECD study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity : 95.4 % (contains about 4.6 % water)

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.7
Temp.:
23 °C
pH:
ca. 2.1

Any other information on results incl. tables

determ. no. stock solution water test substance conc. test substance conc. Log Pow

[ml] [ml] in n-octanol phase [mg/l] in water phase [mg/l]

A1 10 20 38,6 5,4 0,85

A2                 10                  20 38,4 5,4 0,85

B1                  20 20 40,9 7,8 0,72

B2 20 20 38,6 7,9 0,69

C1 40 20 40,9 12,4 0,52

C2 40 20 43,2 12,4 0,54

mean --- --- --- --- 0,70

Recovery rate: 94 - 100%

HPLC conditions:

Column : Synergi Polar RP, 250 mm x 4,6 mm ID, 4 μm

Eluent A : acetonitrile/water with 0,05mol/l tetrabutyl ammonium hydrogensulfate = 5/95

Applicant's summary and conclusion

Conclusions:
The Log Pow of the substance is 0.7 at 23 °C.
Executive summary:

The partition coefficient n-octanol / water of the susbstance was determined according OECD guideline 107 (flask method), using HPLC for the analytical determination. Log Pow was found to be 0.7 at 23 °C.