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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Remarks:
other: Category approach based on OECD-404 data within the APP category.
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Category is coherent for more than 10 endpoints. If skin irritation occured it would be related to the properties of surfactant and 2 substances in the category do not exhibit any skin irritation effect.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014

Materials and methods

Principles of method if other than guideline:
Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and grouping of chemicals - May 2008
GLP compliance:
no
Remarks:
Not relevant for a category approach.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 72h
Score:
ca. 0
Max. score:
0
Reversibility:
other: Not relevant, as no effect

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to OECD-404 (reliability) absolutely no effect occurs when APP-6505 or APP-6781 are applied on a damaged rabbit skin. Within a category approach (see APP category report) it can be concluded with good confidence that APP-6512 is also not a skin irritant.