Registration Dossier
Registration Dossier
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EC number: 910-704-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The substance is considered to be irritating to skin and the respiratory system and entails a risk of serious damage to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The results of an available in vivo skin irritation studies (rabbit) indicate that the substance may be irritating to skin (pH effect), by read-across from Ca(OH)2. In the available eye irritation study (in vivo, rabbit), Ca(OH)2 caused irreversible lesions in the eye. By read across the results are also applicable for “Reaction mass of Limestone and dicalcium silicate”. From human data on calcium oxide and hydroxide it is concluded by read-across (worst case approach) that target substance is irritating to the respiratory tract.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based on experimental results on a similar substance utilised by read-across, “Reaction mass of Limestone and dicalcium silicate” requires classification as irritating to skin (R38, irritating to skin; Skin Irrit 2 (H315 – Causes skin irritation)) and as severely irritating to the eye (R41, Risk of serious damage to eye; Eye Damage 1 (H318 - Causes serious eye damage)). Based on human data as summarised and evaluated in the SCOEL recommendation (Anonymous, 2008: Recommendation from the Scientific Committee on Occupational Exposure Limits for Calcium oxide (CaO) and calcium hydroxide (Ca(OH)2), European Commission, DG Employment, Social Affairs and Equal Opportunities, SCOEL/SUM/137 February 2008, see section 7.2.2 of the technical dossier), it is proposed to classify the substance as irritating to the respiratory system (R37, Irritating to respiratory system; STOT SE 3 (H335 - May cause respiratory irritation)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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