Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Teratogenic study of ethylene and propylene oxide and n-Butyl Acetate
Author:
Hackett PL, Brown MG, Buschbom RL, Clark ML, Miller RA, Music RL, Rowe SE, Schirmer RE, Sikov MR.
Year:
1982
Bibliographic source:
Department of Health and Human Services (US), Centers for Disease Control & Prevention; NIOSH (National Institute for Occupational Safety and Health)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
Molecular formula:
C3H6O
IUPAC Name:
2-methyloxirane

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
LOEC
Effect level:
1 188 mg/m³ air
Based on:
test mat.
Basis for effect level:
other: developmental toxicity

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion