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Toxicological information

Carcinogenicity

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Description of key information

There no data available on phosphonic ester residue with respect to carcinogenicity.
Based on the available data with dimethylphosphonate, phosphonic ester residue has to be suspected of causing cancer

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Study duration:
chronic
Species:
rat

Additional information

There no data available on phosphonic ester residue with respect to carcinogenicity.

Phosphonic ester residue contains monomethyl phosphonate, phosphonic acid, and Dimethylphosphonate, and aand pyrophosphoric acid. and phosphate which were not further specified

Monomethylphosphonate and phosphonic acid

There are no data available

Dimethylphosphonate

In a carcinogenicity study (equivalent to OECD guideline 451) dimethyl phosphonate showed evidence of carcinogenicity in male F344 rats and equivocal evidence in female F344 rats. Target organs were lungs and forestomach. No evidence of carcinogenicity was observed in male and female B6C3F1 mice.(US Health and Human Services 1985, UNEP 2006) The substance is classified as Carc Cat 3 and labelled by producer with R40 resp according to Regulation 1272/2008 (GHS/CLP) allocated to Carc Cat 2 H351= suspected of causing cancer.

Salt of pyrophosphoric acid and phosphate which are not further specified

there are no data available

Overall, based on the available data with dimethylphosphonate and taking into account GHS/CLP Regulation 1272/2008, phosphonic ester residue has to be suspected of causing cancer


Justification for selection of carcinogenicity via oral route endpoint:
There no data available on phosphonic ester residue with respect to carcinogenicity.
Based on the available data with dimethylphosphonate phosphonic ester residue has to be suspected of causing cancer

Justification for classification or non-classification

According to GHS/CLP Regulation 1272 / 2008 section 3.6.3. Classification criteria for mixtures: a mixture will beclassified as carcinogen wheb at least one ingredient has been classified as a Category 1A Category 1 B or Category 2 carcinogen and is present at or above the appropriate generic concentration limit as shown in the respective table.

This requirement is fulfilled for dimetnylphosphonate accounting for 11 % in phosphonic ester residue which is

classified as Carc Cat 3 and labelled by producer with R40 resp according to Regulation 1272/2008 (GHS/CLP) allocated to Carc Cat 2 H351= suspected of causing cancer.

Consequently phosphonic ester residue has to be classified / labelled Cat 3 R40 according to 67/548 ESG and allocated to category 2 of carcinogenic substances H351= suspected causing cancer