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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: secondary citation in a peer Review based on a guideline study

Data source

Reference
Reference Type:
secondary source
Title:
Hoechst AG (1985): Unveröffentl. Unters. (Ber.-Nr. 85.0015)
Author:
European Chemical Bureau (ECB)
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
physiological saline
Controls:
not specified
Amount / concentration applied:
500 mg/patch
Duration of treatment / exposure:
3 min and 4 hours
Observation period:
according to guideline: no details given
Number of animals:
according to guideline: no details given
Details on study design:
according to the respective guideline

Results and discussion

In vivo

Results
Irritation parameter:
other: the sloggy test substance was evaluated corrosive
Basis:
other: the sloggy testsubstance was evaluated corrosive
Time point:
other: 3 min or 4 hours, respectively
Reversibility:
other: the sloggy testsubstance was evaluated corrosive
Remarks on result:
other: no details given
Irritant / corrosive response data:
the test substance was evaluated corrosive

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria
Conclusions:
Classification: highly corrosive (causes severe burns)
Executive summary:

Phosphonic acid is tested for skin irritation according to OECD TG 403 and revealed to be corrosive.

ECB (2000):

SO-Freetext: Hoechst AG  Frankfurt/Main
Hoechst AG  Frankfurt/Main
Clariant GmbH  Frankfurt am Main:

Only the sloggy product was corrosive to the skin