Registration Dossier
Registration Dossier
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EC number: 909-044-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: secondary citation in a peer Review based on a guideline study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Hoechst AG (1985): Unveröffentl. Unters. (Ber.-Nr. 85.0015)
- Author:
- European Chemical Bureau (ECB)
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phosphonic acid
- EC Number:
- 237-066-7
- EC Name:
- Phosphonic acid
- Cas Number:
- 13598-36-2
- Molecular formula:
- H3O3P
- IUPAC Name:
- phosphonic acid
- Test material form:
- other: liquid
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg/patch
- Duration of treatment / exposure:
- 3 min and 4 hours
- Observation period:
- according to guideline: no details given
- Number of animals:
- according to guideline: no details given
- Details on study design:
- according to the respective guideline
Results and discussion
In vivo
Results
- Irritation parameter:
- other: the sloggy test substance was evaluated corrosive
- Basis:
- other: the sloggy testsubstance was evaluated corrosive
- Time point:
- other: 3 min or 4 hours, respectively
- Reversibility:
- other: the sloggy testsubstance was evaluated corrosive
- Remarks on result:
- other: no details given
- Irritant / corrosive response data:
- the test substance was evaluated corrosive
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- Classification: highly corrosive (causes severe burns)
- Executive summary:
Phosphonic acid is tested for skin irritation according to OECD TG 403 and revealed to be corrosive.
ECB (2000):
SO-Freetext: Hoechst AG Frankfurt/Main
Hoechst AG Frankfurt/Main
Clariant GmbH Frankfurt am Main:Only the sloggy product was corrosive to the skin
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