Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given. Adopted from OECD SIDS. The original source is available and has been reviewed.
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1992
Report Date:
1992
Reference Type:
secondary source
Title:
Dimethyl phosphonate - CAS No: 868-85-9 - SIDS Initial Assessment Report.
Author:
OECD
Year:
2006
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Ten male rats were exposed to 7100 mg/m³ dimethyl phophonate (calculate exposure concentration from air flow and net loss of material) for 6 hours.


GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study
Test type:
other: no data
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): dimethyl phosphonate
- Substance type: technical product
- Assumed purity: 100%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
-Housing: at termination of the exposure the animals were housed by species in metal cages elevated above the droppings.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
-Animals were exposed for 6 hours to the near saturated vapours of the test materials. Each exposure was conducted in a 500-liter stainless steel inhalation chamber equipped at the inlet with one or two fritted-disc glass bubblers which contained the test material. A glass trap was placed in the line between this vapour generator and the chamber to collect any entrained liquid. The air flow through the system was 18 liters per minutes (one bubbler), or 35 liters per minute (two bubblers). Dimethyl phosphonate vapour was generated at room temperature.
No attempt was made to determine the actual chamber concentration during the exposure. The mean theoretical concentration was calculated for each material from the air flow and net loss material.



Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
6 h
Concentrations:
7100 mg/m³
No. of animals per sex per dose:
10 (male rats)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days.
- Other examinations performed: mortality, toxic effects, autopsy.
Statistics:
Not performed

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 7 100 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
6 h
Mortality:
no deaths
Clinical signs:
other: no clinical signs
Body weight:
No data
Gross pathology:
Congestion and hemorrhage in the lungs.
Other findings:
No further data

Any other information on results incl. tables

Based on the study results and according to DSD-DPD and CLP classification criteria, the test substance is not to be classified.

Applicant's summary and conclusion

Executive summary:

Ten male rats were exposed to 7100 mg/m³ dimethyl phosphonate (calculated exposure concentration from air flow and net loss of material) for 6 hours. No deaths occurred. ongestion and hemorrhage in the lungs were observed in rats

Occidental Chemical Corporation (1992)

. Based on the study results and according to DSD-DPD and CLP classification criteria, the test substance is not to be classified.