Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: although data from handbook without details on the method the result can contribute to the evaluation

Data source

Reference
Reference Type:
review article or handbook
Title:
Prehled Prumyslove Toxikologie; Organicke Latky
Author:
Marhold J
Year:
1986
Bibliographic source:
Avicenum, page 1114

Materials and methods

Principles of method if other than guideline:
invivo test with rats (no details)
GLP compliance:
not specified
Test type:
other: in vivo test with rats

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
no details given

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no details given
Doses:
no details given
No. of animals per sex per dose:
no details given
Control animals:
not specified
Details on study design:
no details given
Statistics:
no details given

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 740 mg/kg bw
Mortality:
no details given
Clinical signs:
no details given
Body weight:
no details given
Gross pathology:
no details given

Applicant's summary and conclusion

Executive summary:

Marhold (1986) reported LD50(rat, oral) = 1740 mg/kg bw, details were not given.