Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication which meets basic scientific principles
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Analysis of Dimethyl Hydrogen Phosphite and Its Stability under Simulated Physiological Conditions
Author:
Nomeir AA, Burka LT, Matthews HB
Year:
1988
Bibliographic source:
J Analytical Toxicol 12(6): 334 - 338

Materials and methods

Principles of method if other than guideline:
The investigation was carried out to study the stability of DMP under conditions similar to those that the chemical may encounter in the physiological environment (lungs, forestomach). Capillary gas chromatography (GC) was used to analyze DMP. The decomposition products of DMP were identified by HPLC and proton nuclear magnetic resonance spectroscopy (H-NMR).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Dimethyl Hydrogen Phosphite
- Analytical purity: >99%
- Source: Aldrich Chemical Company, Inc.

Results and discussion

Water solubility
Water solubility:
> 100 g/L
Temp.:
22 °C
pH:
> 2 - < 8

Any other information on results incl. tables

Preparation of 10 % (w/v) of dimethyl phosphonate solution in deionized water, in HCl at pH 2 and in 0.1M sodium phosphate buffer at pH 7 and pH 8 was possible at room temperature (22°C).

Hydrolysis was observed.

Hydrolysis products were:

monomethyl hydrogen phosphite and methanol and further phophorous acid and methanol.

pH values of all solutions decreased progressively as time passed.

Applicant's summary and conclusion