Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short analysis report, raw data not reported but still considered reliable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The goal of the study was to demonstrate the actual product appearance and establish the existence of the agglomerates.
Particle size (PS) distribution of Aluminum Super Phosphate (AlASP) was measured in water and Methylene Chloride. - GLP compliance:
- no
- Type of distribution:
- volumetric distribution
Test material
Constituent 1
Results and discussion
Particle sizeopen allclose all
- Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- Percentile:
- D50
- Mean:
- 168.488 µm
- Remarks on result:
- other: In water without sonication
- Percentile:
- D50
- Mean:
- 151.589 µm
- Remarks on result:
- other: In water with sonication
- Percentile:
- D50
- Mean:
- 121.791 µm
- Remarks on result:
- other: In methylene chloride with sonication
Any other information on results incl. tables
The first measurement was done in water with without sonication. The histogram visibly shows that ca. 40% of AlASP sample is agglomerates with diameters > 200 µm. After sonication, the second measurement histogram clearly changes and the overall particle size is measurably reduced.
A third measurement was done in methylenechloride after sonication. The measurement results revealed similar PS distribution with comparison to the measurements done in water after sonication.
Applicant's summary and conclusion
- Conclusions:
- The difference in the histograms and the particles size reduction in both solvents proves that the product contain agglomerates.
The large initial particle size and the strong tendency to form agglomerates reduces the possibility of the substance particles dispersing in air and becoming airborne, and thus, minimizes the availability of the substance through the inhalation route.
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