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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: test conducted according to the respective OECD guideline and under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid
EC Number:
700-740-0
Cas Number:
1103234-56-5
Molecular formula:
C10H11F2NO4S
IUPAC Name:
2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid
Details on test material:
-Substance type: organic
-Physical state: white powder
-Storage condition of test material: at room temerature, protected from light

Results and discussion

Water solubility
Water solubility:
> 944 - < 981 g/L
Temp.:
20 °C
pH:
> 2.5 - < 2.8
Details on results:
The initially added amount of test substance was 5 g per litre deionised water. The
measured concentrations were:
944 mg/1 (24 h), 935 mg/1 (48 h) and 981 mg/1 (72 h). The pH values of the solutions
were 2.8, 2.7 and 2.5, respectively.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
Based on the measured concentrations, the water solubility was determined to be
953 mg/1 at 20 ± 0.5°C and a pH of 2. 7.