Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
other: calculation
Type of information:
(Q)SAR
Adequacy of study:
other information
Study period:
2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR System - Total domain, structural and parametric domain were calculated to be "in domain".
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A quantitative structure-activity relationship (QSAR) system for the estimation of the skin sensitization potency that incorporates skin metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with skin proteins. A chemically divers training set was used and their skin sensitization potency assigned to one of three classes.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Decanenitrile
EC Number:
217-830-6
EC Name:
Decanenitrile
Cas Number:
1975-78-6
Molecular formula:
C10H19N
IUPAC Name:
decanenitrile

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
Based on the results of this investigation, decanenitrile does not need to be classified for skin sensitization according to Regulation (EU) 1272/2008 and Directive 65/548/EEC.