Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Key study: experimental result from a study report in guinea pigs, according to EC-directive 96/54, B.6., "Skin Sensitization" and the OECD-guideline 406, "Skin Sensitisation", by the "maximisation test".

There were two induction exposures (intradermal and epicutaneous) and one challenge exposure. Application of Freund's complete adjuvant was included in the intradermal exposure of both groups to enhance a possible sensitisation. For the epicutaneous exposures occlusive dressings were used.

Results showed no relevant systemic toxic signs . Neither animals of the test substance group in step 1 had positive skin reactions nor animals of the test substance group in step 2 had positive skin reactions at the test substance treated sites 24 hours and/or 48 hours after the end of the exposure. No adverse skin reactions were observed in the control animals. Therefore no animal of the test substance group was regarded as sensitised.


Migrated from Short description of key information:
Skin sensitisation: key study: results from a study report leading to the conclusion that Zirkonium-tetrakis(isobutyrato) is not sensitizing.

Justification for classification or non-classification