Registration Dossier
Registration Dossier
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EC number: 619-635-5 | CAS number: 12567-73-6
Endpoint summary
Administrative data
Description of key information
In vivo skin irritation/corrosion: key study: Zirkonium-tetrakis(isobutyrato) is not irritationg for skin.
n vivo eye irritation: key study : Zirkonium-tetrakis(isobutyrato) is not irritationg for eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation: Key study: experimental results from a study report in rabbits, according to OECD Guideline 404 and the Directive 2004/73/EC, method B.4. Single application, semi-occlusive dressing, 4 hours exposure.
The mean scores for all animals were Erythema / Eschar: 0 and Oedema: 0. All areas to be treated with the test substance and all control areas were normal before the application and at each observation time. The substance was not irritating.
Eye irritation: In vivo eye irritation: key study in rabbits, according to OECD Guideline 405 and the Directive 2004/73/EC, method B.5.
After the instillation of the test substance, the following findings were made:
Corneae: Not affected.
Irises: Not affected.
Conjunctivae, redness: A score of "1" in all animals from 1 h or 24 h p.a. onwards until a maximum of 72 h p.a.
Conjunctivae, chemosis: A score of "1" in all animals from 1 h onwards until a maximum of 24 h p.a.
Additional findings: Ocular discharge was noted in 1/3 animals only 1 h p.a.
Ocular lesions were reversible in all animals within 7 d p.a.
The substance was not irritating.
Justification for classification or non-classification
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