Registration Dossier

Toxicological information

Carcinogenicity

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Description of key information

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Additional information

For reaction mass of aluminium hydroxide and aluminium nitrate and aluminium sulphate there are no data for carcinogenicity.

According to the REACh regulation (1907/2006/EC), a carcinogenicity study may be proposed by the registrant or may be required by the Agency in accordance with Articles 40 or 41 if the substance has a widespread dispersive use or there is evidence of frequent or long-term human exposure, and the substance is classified as mutagen category 3 or there is evidence from repeated dose studies that the substance is able to induce hyperplasia and/or pre-neoplastic lesions.

There is no evidence, that the substance causes carcinogenicity by a direct genotoxic mechanism as this is not indicated by the weight of evidence based on data regarding aluminium containing compounds (see Genetic toxicity). Furthermore, in long-term studies with different aluminium compounds, there was no evidence for preneoplastic lesions (see Repeated dose toxicity).