Registration Dossier
Registration Dossier
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EC number: 500-057-6 | CAS number: 27104-30-9
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.006 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 14.2 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.004 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.335 mg/kg soil dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
- Assessment factor:
- 1
Additional information
The technical product "Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea" (THPC-urea) is a condensate of THPC and urea. The functional group of the THPC is the OH group. The functional group of the urea is the amino group NH2. The condensation of THPC and urea does not change both functional groups.
The first read across approach between THPC and THPS is considered applicable, as the organic phosphonium cation, which is the responsible part for the toxicological effects, is the same for both salts. The different anions (chlorid and sulfat) have no great influence on the solubility (both very high), the vapour pressure (both extrem low), and the log Kow (both extrem low and negativ).
The second read-across approach between THPC and THPC-urea is based on the fact, that THPC is an impurity of the technical product THPC-urea. THPC is more reactive and more toxic than THPC-urea. A worst case scenario is created assuming that THPC-urea is completely reactive like THPC.
Furthermore, the oxidative degradation of THPC-urea, THPS and THPC results in the same main metabolite THPO, which is far less toxic than THPC-urea, THPS and THPC.
Conclusion on classification
Based on available data the C&L as aquatic acute 1 (H400) as well as aquatic chronic 1 (H410) is justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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