Registration Dossier
Registration Dossier
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EC number: 500-057-6 | CAS number: 27104-30-9
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- other: publications
- Adequacy of study:
- key study
- Study period:
- not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The publications about Hydrolysis of THPX species refer to good quality studies.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 963
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The publications refer to hydrolysis studies at different pHs (5, 7, 11) with analytics.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
- EC Number:
- 500-057-6
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
- Cas Number:
- 27104-30-9
- Molecular formula:
- C5H16ClN2O5P
- IUPAC Name:
- Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), polymer with urea
Constituent 1
- Radiolabelling:
- not specified
Study design
- Analytical monitoring:
- not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
Results and discussion
- Preliminary study:
- It could be shown with 31P-NMR analytic during a Zahn-Wellens-Test that after 24 days the parent compound THPC-urea oligomer has completely disappeared. As major metabolites trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA) were both found analytically.
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- THPO, Tris-(hydroxymethyl)-phosphinoxide
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- BMPA, Bishydroxymethyl phosphonic acid
- Details on hydrolysis and appearance of transformation product(s):
- Hydrolysis of THPC-urea is highly pH-dependent, as it is for THPC and THPS also. The fastest degradation occurs at pH 11. Major metabolites were trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA), which were both found.
- Other kinetic parameters:
- Degradation of THPS follows the first-order kinetics.
- Details on results:
- Hydrolysis of THPC-urea is highly pH-dependent, as it is for THPC and THPS also. The fastest degradation occurs at pH 11. Major metabolites were trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA), which were both found.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Hydrolysis of THPC-urea is highly pH-dependent, as it is for THPC and THPS also. The fastest degradation occurs at pH 11. Major metabolites were trihydroxymethyl phosphine oxide (THPO) and bishydroxymethyl phosphonic acid (BMPA), which were both found in the water.
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