Registration Dossier
Registration Dossier
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EC number: 420-380-5 | CAS number: 136465-81-1
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Modern GLP study performed using an acceptable method for the determination of the dissociation constant. However, the test does not completely fulfill the OECD guideline 112. Limited measurements are taken to determine the pKa and no reference substances are employed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Principles of method if other than guideline:
- Only two measurements are taken to determine the pKa using the titration method. No reference substances are employed.
- GLP compliance:
- yes
Test material
- Reference substance name:
- PTH-decahydroamide
- IUPAC Name:
- PTH-decahydroamide
- Reference substance name:
- Ro 31-9373/000
- IUPAC Name:
- Ro 31-9373/000
- Details on test material:
- The test material received from F. Hoffmann-La Roche Ltd was a white solid powder from lot no. 25927 with a purity of 99.8%.
Constituent 1
Constituent 2
Results and discussion
- Dissociating properties:
- not determined
Dissociation constant
- No.:
- #1
- pKa:
- 8.64
- Temp.:
- 24 °C
- Remarks on result:
- other: average of two measurements
Any other information on results incl. tables
The average pKa (two measurements) calculated by the Titrator processor was 8.64 ±0.07.
Applicant's summary and conclusion
- Conclusions:
- The average pKa (two measurements) calculated at 24 °C by the Titrator processor was 8.64 ±0.07.
- Executive summary:
An aqueous solution of PTH-Decahydroamide was titrated by a 0.01 N solution of hydrochloric acid using a Mettler titrator, type DL25. The average pKa (two measurements) calculated at 24 °C by the Titrator processor was 8.64 ±0.07.
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