Registration Dossier
Registration Dossier
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EC number: 700-941-3 | CAS number: 1512859-54-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Cuprate(4-), [2-[[4-chloro-6-[ethyl[3-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-5-(hydroxy-kO)-6-[2-[2-[2-[2-(hydroxy-kO)-5-sulfophenyl]diazenyl-kN1]-4,5-dimethoxyphenyl]diazenyl-kN2]-1,7-naphthalenedisulfonato(6-)]-, hydrogen sodium (1:2:2)
- EC Number:
- 700-941-3
- Cas Number:
- 1512859-54-9
- Molecular formula:
- C37H28ClCuN9O19S5 . 2 Na . 2 H
- IUPAC Name:
- Cuprate(4-), [2-[[4-chloro-6-[ethyl[3-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-5-(hydroxy-kO)-6-[2-[2-[2-[2-(hydroxy-kO)-5-sulfophenyl]diazenyl-kN1]-4,5-dimethoxyphenyl]diazenyl-kN2]-1,7-naphthalenedisulfonato(6-)]-, hydrogen sodium (1:2:2)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Dose volume: 10 mL/kg, the actual dosing volume was adjusted based on the individual body weight before dosing.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 6; Number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels: No clinical signs of systemic toxicity were noted. Black faeces and urine was noted among all animals on day 2, which was considered to be related to staining properties of the formulation (black colour).
- Gross pathology:
- Effects on organs:
No gross lesion was found in all animals.
Any other information on results incl. tables
| Gross Necropsy | |||||||
| Animal ID. | Results | ||||||
| 1120150018 | No gross lesion was observed | ||||||
| 1120150015 | |||||||
| 1120150003 | |||||||
| 1120150002 | |||||||
| 1120150011 | |||||||
| 1120150017 | |||||||
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Based on the data obtained from this study, the test article of Everzol SB46 would be assigned to GHS Category 5/unclassified and the harmonized
LD50 cut-off value is above 2000 mg/kg body weight.
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