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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 471/ 84/449/EWG B.14/ Ames-Test
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
EC Number:
413-610-0
EC Name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
Cas Number:
124172-53-8
Molecular formula:
C26H50N4O2
IUPAC Name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide

Method

Species / strain
Species / strain / cell type:
bacteria, other: sat TA98,100,1535,1537
Metabolic activation system:
Aroclor-induced rat liver S9 mix
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation): 20 ... 5000µg/plate
Concentration range in the main test (without metabolic activation): 20 ... 5000µg/plate
Vehicle / solvent:
Solvent: DMSO

Results and discussion

Any other information on results incl. tables

Comments:

For the bacterial toxic concentration

b) imHaupt-TestohnemetablischeAktivierungnurmitTA98 imPrinkuloationstestbei5000myg/Platte

KonzentrationderTestsubstanz, beiderAusfllungauftritt :GallstndigeLslichkeit

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation