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EC number: 921-820-3 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Considering the chemical is readily biodegradable and its different components (degradation products: alcohols and glucose),we can expect a low bioaccumulation potential. Considering finally the difficulty for testing and to obtain reliable results, we do not propose further testing on bioaccumulation.
Key value for chemical safety assessment
Additional information
No experimental data on aquatic bioaccumulation are available.
There is reasonable doubt about the accuracy to perform measured data of log Kow (e.g. due to problems with analytical methods or surfactant properties), the log Kow value was calculated using validated QSARs. As multiple logs Kow data are available for the same substance, due to the fact this is a UVCB. Generally, the highest valid value should take precedence. Further details are provided in chapter R.7.1.
The study to determine the partition coefficient (log Kow) gives data ranging from 2.9 to 10.7, indicating a high bioaccumulation potential.
This study was performed by QSAR estimation as the chemical is a insoluble UVCB, very difficult to test.
The substance contains about 2.2% of tetracosanol (C24 alcohol) with a log Log Kow =10.7. The alkyl chain length has the highest impact on the log Kow value.
For highly hydrophobic substances (e.g. with log Kow >6), the available BCF models (typically BCFWIN, BCFmax and the ‘modified Connell’ equation) can lead to very different results. As a consequence, the potential for bioaccumulation is assessed by expert judgement on the basis of thelog Kow value, the estimated BCF using the available models and additional available information including structural information.
A quantitative estimation of the bio concentration factor (BCF) for fish can be performed according to the parabolic equation given in the guidance on information requirements and chemical safety assessment (Chapter R7c) for substances having a log Kow>6:
Parabolic equation:
Log BCFfish= -0.20 x(log Kow)² +2.74 x log Kow-4.72
Log BCFfish=-0.20 x (10.7)² + 2.74x7.7-4.72
Log BCFfish=2, 5
BCFfish=316
Considering the chemical is readily biodegradable and its different components (degradation products: alcohols and glucose),we can expect a low bioaccumulation potential. Considering finally the difficulty for testing and to obtain reliable results, we do not propose further testing on bioaccumulation.
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