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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
grey literature
Title:
Unnamed
Year:
1959
Report date:
1959

Materials and methods

Principles of method if other than guideline:
Test method not available.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-amino-6-chlorobenzene-1,3-disulphonamide
EC Number:
204-463-1
EC Name:
4-amino-6-chlorobenzene-1,3-disulphonamide
Cas Number:
121-30-2
Molecular formula:
C6H8ClN3O4S2
IUPAC Name:
4-amino-6-chlorobenzene-1,3-disulfonamide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Vehicle:
not specified
Duration of treatment / exposure:
six weeks
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
100 or 300 mg/kg bw
Basis:
nominal in diet
Details on study design:
In order to avoid an excessive salt depletion the rats had a supplement of potassium chloride in the drinking water on Sunday.

Results and discussion

Results of examinations

Details on results:
The rats grew normally, and autopsy with histological examination of the kidneys showed no pathological changes attribuitable to the diuretic.

Effect levels

Sex:
not specified
Basis for effect level:
other: The rats grew normally, and autopsy with histological examination of the kidneys showed no pathological changes attribuitable to the diuretic.
Remarks on result:
not measured/tested
Remarks:
Effect level not specified (migrated information)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The rats grew normally, and autopsy with histological examination of the kidneys showed no pathological changes attribuitable to the diuretic.

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