Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The skin sensitising potential of 2,3 -bis((2 -mercaptoethyl)thio)-1-propanethiol was evaluated in a study performed under GLP and according to U.S. EPA Pesticide Assessment Guidelines, Subdivision F, Part 81 -6, similar to the Guinea Pig Maximisation Test of Magnusson and Kligman (Mitsui 1993, SNIF#001-4.1.70 -01). No skin effects were observed in the animals challenged with the test substance. Therefore, 2,3-bis((2 -mercaptoethyl)thio)-1-propanethiol is not considered to be sensitising under the test conditions.

The skin sensitising potential of 2,3 -bis((2 -mercaptoethyl)thio)-1-propanethiol was evaluated in a study performed under GLP and according to U.S. EPA Pesticide Assessment Guidelines, Subdivision F, Part 81 -6, similar to the Guinea Pig Maximisation Test of Magnusson and Kligman (Mitsui 1993, SNIF#001-4.1.70 -01). No skin effects were observed in the animals challenged with the test substance. Therefore, 2,3-bis((2 -mercaptoethyl)thio)-1-propanethiol is not considered to be sensitising under the test conditions.

However, observations with the test substance at the production plant reported by the manufacturer lead us to conclude that there is evidence that the substance could be a skin sensitiser in humans.


Migrated from Short description of key information:
There is sufficient information from experience in humans that DMPT could be a skin sensitiser. This is in contrast to the guinea pig maximisation test conducted in 1993.

Justification for classification or non-classification

According to Annex I of DSD (67/548/EC), the available data on 2,3-bis((mercaptoethyl)thio)-1-propanethiol are sufficient for classification.

According toAnnex VI of CLP (1272/2008/EC), the available data on 2,3-bis((mercaptoethyl)thio)-1-propanethiol are sufficient for classification.