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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Based on Read-Across with 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate

The ADME characteristics were investigated by the oral and IV routes in the rat. The bioavailability after the oral low and high doses were > 100% and approximately 50%, respectively. However, the bioavailability for the high dose was calculated using a lower IV dose. In addition, less than 1% of the parent compound was found in the faeces after the oral high dose, indicating practically complete absorption from the gastrointestinal tract. Therefore, 100% absorption by the oral route is assumed and is taken forward to risk characterisation. No sex difference was observed in blood kinetics at the low dose, however, in the high dose group, Cmax and AUC were higher in females than males. The elimination half life was 99-113 hours, irrespective of the dose, route or sex. The retention of radioactivity was low, with the majority (60%) of the radioactivity excreted by biliary route within 3 days of dosing. Approximately 20% was excreted in urine and a small amount of radioactivity exhaled as14CO2. [14C]-radiolabelled test substance or its metabolites were distributed all over the body, but no target organs, other than organs of elimination were identified. The major metabolites which could be identified were found in the faeces.


An in vitro percutaneous absorption study using human skin membranes in flow-through diffusion cells was conducted to determine the rate and extent of absorption following topical application [14C] radiolabelled material, either “neat” or in an ethanol vehicle, to human skin. The skin membranes were exposed for 8 hours, mimicking a normal working day. The dermal delivery for the test substance and the substance in ethanol (0.2 mg/cm2) was 0.51 % and 6 %, respectively.