Registration Dossier
Registration Dossier
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EC number: 700-854-0 | CAS number: 256473-04-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 55.8 mg/L
- EC10 or NOEC for freshwater algae:
- 16.5 mg/L
Additional information
The growth inhibition of CTFEP (purity 91 4 %) to Pseudokirchneriella subapitata was determined in a 72 h static GLP algae growth inhibition test (Maetzler, 2001). The test design was based on the OECD 203 guideline and the EU method C.3.Since the study was performed under GLP and according the guideline and based on the good documentation the study was awarded with Klimisch 1. The nominal test concentrations were Control (0), 4.3, 9.4, 21, 45 and 100 mg test item/L, corresponding to corresponding to mean measured 0 (control), 3.38, 7.31, 16.1, 35.1, and 76.3 mg CTFEP/L. Six control replicates and 3 replicates from each test solution were set up. Dose verification analysis was performed. In order to determine the growth of the cultures, the cells were counted electronically. The test was started with 10000 cells/mL. The cell density was determined at 24, 48 and 72 hours. The growth of the control cultures fulfilled the validity criteria from OECD 201 (2006). The 72 -hour NOEC, ErC10 and ErC50 are 16.5, 24.7, and 55.8 mg CTFEP/L based on the mean measured concentration.
The obtained results are considered as relevant for the risk assessment.
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