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EC number: 903-919-3
CAS number: -
Test atmosphere concentrations
The test atmosphere concentration was sampled five times during
the exposure. The actual concentration of the test item was calculated
as the average of the concentrations obtained from gravimetry of the
samples. The test item appeared as vapour, however, a small amount of
aerosol was also detected in the cascade impactor. The aerosol particles
presented approximately 0.04 % of the total mass of the test item in the
Mean Achieved Concentration
Individual Body weight data:
Body weight (g)
Weekly Increase (g)
*Difference in %
toxicity of test item reaction mass
of 2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA)
was tested under GLP and according to OECD 403 and EU B.2 guidelines. A
group of ten Wistar Crl:(WI) BR rats (five males and five females) was
exposed to an atmosphere that contained the vapour and in small fraction
(0.04 %) the aerosol of the test item. The animals were exposed for four
hours using a nose-only exposure system, followed by a fourteen day
observation period. The mean achieved atmosphere concentration was 21.0
+/- 2.21 mg/L.
In all male and female
animals test item related clinical signs were found after removal from
restraint on completion of the exposure. One hour after the exposure all
All male and female animals were
symptom-free from first day of observation period. The clinical signs
represented the decreased activity and general reaction, tremor,
incoordination and sleeping. On basis of body weight and body weight
gain data, there was no notable test item effect observable in the
A single four hours nose-only exposure
oftest item reaction mass of
2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA)
to CRL: (WI) BR rat followed by a 14-day observation period at a dose
level 21.0 mg/L was not associated with any test item-related
macroscopic findings on the male and female animals.
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