Registration Dossier
Registration Dossier
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EC number: 903-919-3 | CAS number: -
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study under GLP, according to international guidelines and with full documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sample 2010
- IUPAC Name:
- Sample 2010
- Details on test material:
- - The analysis was performed for the reference sample "Sample 2010" as defined in Section 1.4
Constituent 1
Results and discussion
Any other information on results incl. tables
One hour after the exposure all animals slept. All male and female animals were symptom-free from first day of observation period.
Applicant's summary and conclusion
- Conclusions:
- Reaction mass of 2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA) has to be classified as Category 3 for narcotic effects.
- Executive summary:
Narcotic effects of reaction mass of 2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA) were observed during testing of acute inhalation toxicity (nose-only) with the test item according to the OECD 403 guideline under GLP.
One hour after the exposure all animals slept. All male and female animals were symptom-free from first day of observation period. Consequently, reaction mass of 2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA) has to be classified as Category 3 (H336) for narcotic effects according to Directive 1999/45/CE and Regulation (EC) 1272/2008.
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