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Diss Factsheets
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EC number: 940-543-9 | CAS number: 354-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Although the test method is not in agreement with current official guidelines and study details are not fully reported, the results are sufficient to aim a conclusion for the health hazard assessment of the substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two drops of the substance were introducted into the conjunctival sac of the rabbits. Changes were registered after 1, 24 and 72 hours, and 7 days. The degree of damage to the mucous membranes of the eyes caused by these compounds was assessed qualitatively based on changes in the cornea, iris and conjunctiva.
No information on washing are reported. No information on the number of animals and the negative control. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,2-trichloro-1,2-difluoroethane
- EC Number:
- 940-543-9
- Cas Number:
- 354-15-4
- Molecular formula:
- C2HCl3F2
- IUPAC Name:
- 1,1,2-trichloro-1,2-difluoroethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): R122
- Molecular formula: CHCIF–ССI2F
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- single administration
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- not reported
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- not determined
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- No determined
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- No score determined
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Remarks:
- palpebral fissure completely closed, diffuse corneal opacity developed, conjunctival hyperemia and inflammatory edema of the eyelids was observed.
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- no score determined
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Remarks:
- palpebral fissure completely closed, diffuse corneal opacity developed, conjunctival hyperemia and inflammatory edema of the eyelids was observed.
- Other effects:
- Immediately after the application of refrigerants, the animals displayed sharp excitement.
After 1 hour, the palpebral fissure completely closed, diffuse corneal opacity developed, conjunctival hyperemia and inflammatory edema of the eyelids was observed.
After 24 and 72 hours, the severity of the described processes decreased, and a week later the changes almost disappeared.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Conclusions:
- Under the reported study, HCFC 122a exhibited irritating effect on the mucous membranes of the eyes.
- Executive summary:
The objective of the research was to study the toxicity of refrigerants HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds was made and toxicological tests on HFCF 122a and HCFC 132 were performed, including studies of skin-absorption, eye irritating and skin sensitizing properties.
To identify the substance action on conjunctiva, the test solutions of HCFC 122a and HCFC 132
were introduced into the conjunctival sac of rabbit eyes; besides, local action of the substances was studied by Draize method.
Two drops of the substances were introducted into the conjunctival sac of the rabbits. Changes were registered after 1, 24 and 72 hours, and 7 days. The degree of damage to the mucous membranes of the eyes caused by these compounds was assessed qualitatively based on changes in the cornea, iris and conjunctiva.
Studies showed that immediately after the application of refrigerants, the animals displayed sharp excitement. After 1 hour, the palpebral fissure completely closed, diffuse corneal opacity developed, conjunctival hyperemia and inflammatory edema of the eyelids was observed. After 24 and 72 hours, the severity of the described processes decreased, and a week later the changes almost disappeared; HFCF 122a caused more severe irritation than HCFC 132.
The study authors established that the test compounds exhibit slight irritating effect on the mucous membranes of the eyes, wherein these properties are more pronounced in HFCF 122a.
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