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Diss Factsheets
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EC number: 940-543-9 | CAS number: 354-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- The data source is the competent authority, it is considered reliable. Although the test method was not specifically conducted for the assessment of the skin irritating potential, the results are sufficient to aim a conclusion for the health hazard assessment of the substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test was conducted in order to assess the skin absorption properties.
The study was conducted in two stages.
At the first stage the substance was applied in a single administration on the skin of the tails of white mice; contact time was 2 hours, after which the tails were washed with soap and water, and the animals were observed for 14 days.
Since the sigle exposure did not cause symptoms of intoxication and death of animals, a repeated applications of the substance for 12 days was included.
At this second stage the substance was applied to the section of rat skin sized 2 x 2 cm, and the application time was 4 hours. In order to prevent evaporation from the skin surface, the studied section of skin was sealed. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,2-trichloro-1,2-difluoroethane
- EC Number:
- 940-543-9
- Cas Number:
- 354-15-4
- Molecular formula:
- C2HCl3F2
- IUPAC Name:
- 1,1,2-trichloro-1,2-difluoroethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): R122
- Molecular formula: CHCIF–ССI2F
Constituent 1
Test animals
- Species:
- other: mouse and rat
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 1 stage: 2h single exposure
2 stage: 4h/day exposure for 12 days - Observation period:
- 1 stage: 14 days
2 stage: no data - Number of animals:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- no score determined
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Remarks:
- Qualitative assessment: signs of dryness followed by redness and cracks after a 12d-exposure period (4h/day); no edema reported.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- no score determined
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
- Remarks:
- Qualitative assessment: signs of dryness followed by redness and cracks after a 12d-exposure period (4h/day)
- Other effects:
- At the end of the experiment, repeated application of refrigerants to the skin (4h/day for 12 days) caused dryness of the skin followed by development of redness and cracks.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Possible irritant effect after repeated application.
- Conclusions:
- Repeated application of HCFC 122a to the skin (4h/day for 12 days) caused dryness of the skin followed by development of redness and cracks. The effects did not meet criteria for classification as a skin irritant but warrant a supplemental hazard statement (EUH066 - Repeated exposure may cause skin dryness or cracking).
- Executive summary:
The objective of the research was to study the toxicity of HCFC 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds was made and toxicological tests on HFCF 122a and HCFC 132 were performed, including studies of skin-absorption, eye irritating and sensitizing properties.
Information on the potential skin irritating properties of HCFC 122a can be obtained from the study of skin absorption.
The study of skin- absorption properties of the substances was conducted in two stages. At the first stage of the experiment, the toxicity of HCFC 122a and HCFC 132 was studied after application of the substances on the skin of the tails of the white mice; contact time was 2 hours, after which the tails were washed with soap and water, and the animals were observed for 14 days.
Single exposure to the substances did not cause symptoms of intoxication and death of animals. Therefore, experiments with repeated applications of HCFC 122a and HCFC 132 for 4 hours/day for 12 days were included.
At the second stage of the experiment, the ability of the substances to penetrate the skin was investigated. The substances were applied to the section of rat skin sized 2 x 2 cm. In order to prevent evaporation of the substances from the skin surface, the studied section of skin was sealed. The functional state of the experimental animals was assessed based on some physiological parameters.
Study showed that repeated application of the two substances to the skin did not lead to changes in appearance and behaviour of animals and changes in functional parameters, indicating the absence of expressed skin-absorption properties. However, repeated application of both the susbtances to the skin at the end of the experiment caused dryness of the skin followed by development of redness and cracks.
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