Registration Dossier
Registration Dossier
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EC number: 200-879-2 | CAS number: 75-56-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats
- Author:
- Eldridge SR, Bogdanffy MS, Jokinen MP, Andrews LS
- Year:
- 1 995
- Bibliographic source:
- Fundam Appl Toxicol 27(1):25-32
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyloxirane
- EC Number:
- 200-879-2
- EC Name:
- Methyloxirane
- Cas Number:
- 75-56-9
- Molecular formula:
- C3H6O
- IUPAC Name:
- 2-methyloxirane
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
Results and discussion
Effect levels
- Dose descriptor:
- LOEC
- Effect level:
- 362 mg/m³ air (nominal)
- Based on:
- other: olfactory cell proliferation
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
