Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Experimental carcinogenicity and acute toxicity of representative epoxides
Author:
Weil CS, Condra N, Haun C, Streigel JA
Year:
1963
Bibliographic source:
Am Ind Hyg Assoc J 24:305-25

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
Molecular formula:
C3H6O
IUPAC Name:
2-methyloxirane

Test animals

Species:
rabbit

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
>= 950 - <= 1 250 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion