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EC number: 915-069-0
CAS number: -
Aluminium sulfate administered via drinking water at 120, 600 or 3000
ppm resulted in decreased water consumption. This change was associated
with decreased food consumption in the 600 and 3000 ppm groups and
decreased body weight in the 3000 ppm group. In the 3000 ppm group, male
and female pups had a lower body weight on PND 21. At this dose, vaginal
opening was slightly delayed. No definitive effects were found in the
other reproductive/developmental parameters, including developmental
A conservative evaluation of the data may led to the conclusion that the
no observed adverse effect level of aluminium sulfate in this
two-generation study is 600 ppm (41.0 mg/kg bw/day) for parental and
Since the dosing solution containing aluminium sulfate was pH 3.57–4.20,
the acidity would decrease the palatability of drinking water in
aluminium sulafte-treated groups. Decreased water consumption was
associated with decreased food consumption by P0 and P1 males and
females in the 600 and 3000 ppm groups and decreased body weight in P0
male and females in the 3000 ppm group. Since water deprived animals
typically reduce their levels of feed consumption and consequently lower
their body weight, decreased food consumption, body weight and absolut
organ weights observed in the present study could be considered
secondary to the decreased water consumption.
Considering these results, substance "reaction mass of calcium hydrogen
phosphonate and dialuminium tricalcium hexaoxide" is not expected to
have an intrinsic toxicity to reproduction deriving from its aluminium
moiety. As the further moieties - calcium and phosphonate - of the
reaction mass do not have an intrinsic toxicity to reproduction either,
substance "reaction mass of calcium hydrogen phosphonate and dialuminium
tricalcium hexaoxide" as such can be expected not to have an intrinsic
toxicity to reproduction.
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