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EC number: 915-069-0
CAS number: -
Table 1: Irritant/corrosive response data
for each animal at each observation time up to removal of each animal
from the test
Score at time point / Reversibility
Area of cornea affected
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (d) for reversion
1) Very slight corneal opacity, rated by
study authors as score 0. Treatment of the eyes with 2 % fluorescein, 24
and 72 hours after test substance instillation revealed corneal
epithelial damage in all three animals.
*) Reversibility: c. = completely
reversible; n.c. = not completely reversible; n. = not reversible
The test substance was considered moderately
irritating to the rabbit eye by a Kay and Calandra interpretation (J.
Society of Cosmetic Chemists, Vol. B no.6, 1962) of the calculated
maximum Draize score of 22.7 (maximum possible score 110).
In a primary eye irritation study according to OECD Guideline No.
405, February 24, 1987 and EEC Directive 84/449/EEC, Part B.5, September
1984, 62 mg (0.1 mL) of substance "reaction mass of calcium hydrogen
phosphonate and dialuminium tricalcium hexaoxide" (90 % a.i.) was
instilled into the conjunctival sac of one eye of 3 young adult New
Zealand white rabbits for 24 hours. Animals were observed for 21 days.
Irritation was scored by the numerical scoring system according to
Draize as given in the guidelines.
Instillation of the substance resulted in reversible adverse
effects on cornea, iris and conjunctivae in all three animals.
The opacity of the cornea was reversible within 7 days after
exposure, the injection of the iris was reversible within 72 hours and
the irritation of the conjunctivae was reversible within 21 days in all
three animals. There was no evidence of ocular corrosion.
In this study, substance "reaction mass of calcium hydrogen
phosphonate and dialuminium tricalcium hexaoxide" (90 % a.i.) is an eye
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