Inositol phosphates

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From April 07, 2009 to May 13, 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The study was conducted according to EU Method A.2 (Boiling Temperature). GLP compliance is claimed through compliance with UK Good Laboratory Practice standards [Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)].

Justification for data waiving:

other:

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Remarks:

using ASTM E537-86

Test material

Test material information

Constituent 1

Reference substance name:

Inositol phosphates

EC Number:

700-206-7

Molecular formula:

As this substance is a UVCB substance and consists varying degree of components, a single molecular formula is not applicable

IUPAC Name:

Inositol phosphates

Constituent 2

Reference substance name:

Synthetic inositol phosphates

IUPAC Name:

Synthetic inositol phosphates

Details on test material:

- Name of test material (as cited in study report): Synthetic Inositol phosphates
- Physical state: Amber coloured liquid
- Lot/batch No.: 95816206JH-012
- Storage condition of test material: Room temperature in the dark

Results and discussion

Boiling point

Atm. press.:

101.32 kPa

Decomposition:

yes

Decomp. temp.:

483 K

Remarks on result:

other: As the test material decomposed, no value for boiling temperature could be determined.

Any other information on results incl. tables

Similar thermographic profiles were obtained using air and nitrogen atmospheres; this indicates that the observed decomposition in both determinations is probably thermal and not oxidative.

                                          

The large endotherm at 368 and 364 K in the two thermograms was considered to be the water component of the test material. The endotherm is broad because the water evaporates as the crucible heats up. Usually, a crucible is sealed with a lid that has a very tiny hole that helps create pressure within the crucible and significantly reduces the loss of material before its boiling temperature. As the test material contained a significant amount of phosphoric acid, it was considered that this could react with an aluminium crucible so platinum crucibles were used. The platinum crucibles were not sealed and have a much larger hole in the lid, preventing the pressure build up, and hence sharper boiling endotherms.

 

A visual appraisal was carried out using a heated metal block apparatus. This demonstrated that the test material decomposed from approximately 465 K by way of the test material colour becoming darker. The colour continued to become darker, until at 503 K the test material had turned to a brown/black colour.

Applicant's summary and conclusion

Conclusions:

The test material was determined to decompose from approximately 483 ± 0.5 deg. K at 101.32 kPa. As the test material decomposed, no value for boiling temperature could be determined.

Executive summary:

A study was conducted to determine the boiling point of synthetic inositol phosphates using differential scanning calorimetry (DSC), according to the procedure specified in ASTM E537-86, EU Method A2 Boiling Temperature.

 

The test material decomposed from approximately 483 ± 0.5 deg. K at 101.32 kPa. Therefore, no value for boiling temperature could be determined.