Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 411-380-6 | CAS number: 147315-50-2 CG 30-1577
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD method, GLP compliance
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD GUIDELINE 407 (84/449/EEC B.7)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
- EC Number:
- 411-380-6
- EC Name:
- 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
- Cas Number:
- 147315-50-2
- Molecular formula:
- C27H27N3O2
- IUPAC Name:
- 2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-(hexyloxy)phenol
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: none
- Details on oral exposure:
- Mode of administration:
admixed in food - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 10 animals at 0 mg/kg bw/day
Male: 5 animals at 8.95 mg/kg bw/day
Male: 5 animals at 59.1 mg/kg bw/day
Male: 10 animals at 1130 mg/kg bw/day
Female: 10 animals at 0 mg/kg bw/day
Female: 5 animals at 8.62 mg/kg bw/day
Female: 5 animals at 55.5 mg/kg bw/day
Female: 10 animals at 1090 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
THERE WERE NO CLINICAL SIGH NOR SIGNS OF SYTEMIC TOXICITY
Laboratory findings:
THE TREATMENT HAD NO INFLUENCE ON THE HEMATOLOGICAL PROFILE
AND NON ON BLOOD CHEMISTRY PARAMTERS
Effects in organs:
NO TREATMENT RELATED CHANGES WERE OBSERVED
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 1 090 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day
- Dose descriptor:
- NOEL
- Effect level:
- 1 090 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
