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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD method, GLP compliance

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD GUIDELINE 407 (84/449/EEC B.7)
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
EC Number:
411-380-6
EC Name:
2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
Cas Number:
147315-50-2
Molecular formula:
C27H27N3O2
IUPAC Name:
2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: none
Details on oral exposure:
Mode of administration:
admixed in food
Duration of treatment / exposure:
Test duration: 28 days
Frequency of treatment:
Dosing regime: 7 days/week
No. of animals per sex per dose:
Male: 10 animals at 0 mg/kg bw/day
Male: 5 animals at 8.95 mg/kg bw/day
Male: 5 animals at 59.1 mg/kg bw/day
Male: 10 animals at 1130 mg/kg bw/day
Female: 10 animals at 0 mg/kg bw/day
Female: 5 animals at 8.62 mg/kg bw/day
Female: 5 animals at 55.5 mg/kg bw/day
Female: 10 animals at 1090 mg/kg bw/day

Results and discussion

Results of examinations

Details on results:
Clinical observations:
THERE WERE NO CLINICAL SIGH NOR SIGNS OF SYTEMIC TOXICITY

Laboratory findings:
THE TREATMENT HAD NO INFLUENCE ON THE HEMATOLOGICAL PROFILE

AND NON ON BLOOD CHEMISTRY PARAMTERS

Effects in organs:
NO TREATMENT RELATED CHANGES WERE OBSERVED

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
1 090 mg/kg bw/day (nominal)
Basis for effect level:
other: original NCD unit is mg/kg/day
Dose descriptor:
NOEL
Effect level:
1 090 mg/kg bw/day (nominal)
Basis for effect level:
other: original NCD unit is mg/kg/day

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Classified as: Not classified