Registration Dossier
Registration Dossier
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EC number: 406-040-9 | CAS number: 125643-61-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP (taken from SNIF file). Registrant referring to studies >12 years old at the permission of ECHA.
Data source
Reference
- Reference Type:
- other: body responsible for the test.
- Title:
- Unnamed
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 406-040-9
- EC Name:
- -
- Cas Number:
- 125643-61-0
- Molecular formula:
- C17 H25 O3 R, Where R = (C7 H15) or (C8 H17) or (C9 H19)
- IUPAC Name:
- Reaction mass of C7-9-alkyl 3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAif (SPF)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0,5 % Carboxymethylcellulose with 0,1 % water soluble Polysorbat 80 solution.
- Doses:
- Male: 2000 mg/kg bw; Number of animals: 5
Female: 2000 mg/kg bw; Number of animals: 5 - No. of animals per sex per dose:
- 5 each sex
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Number of deaths: 0 (both sexes)
- Clinical signs:
- other: Ruffled Fur, abnormal gait and shortness of breath
- Gross pathology:
- No abnormalities where noted at necropsy.
- Other findings:
- All the animals had a rest period of 6 days
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Symptoms noted during the study were considered to be general symptoms of acute tests.
- Executive summary:
Symptoms noted during the study were considered to be general symptoms of acute tests.
No classification is applicable.
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