Registration Dossier

Administrative data

Description of key information

Acute oral toxicity data are available using a standard gavage treatment in adult rats.  No adverse effects on survival or other toxicity parameters were observed at the high limit dose of 2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Toxicity tests were conducted in which KGA were administered to rats. A group of 5 male and 5 female rats were given a dose of 2000 mg/kg bw test substance. The rats were then monitored over the next 15 days for clinical signs and mortality. Body weights were taken on days 0, 2, 4, 6, 8, 11, 13 and 15 of the study. At the termination of the study, all animals were sacrificed, and examined for macroscopic abnormalities. No animals died during the study. No adverse effects to body weight or clinical signs were noted. Therefore, the acute oral LD50 for male and female rats was > 2000 mg/kg bw. The test substance is not classified as toxic under EU GHS guidelines.

Justification for classification or non-classification

No adverse effects were observed in rats given an oral limit dose of 2000 mg/kg bw. Therefore, the acute oral LD50 for male and female rats was > 2000 mg/kg bw. The test substance is not classified as toxic under EU GHS guidelines.