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EC number: 700-720-1 | CAS number: -
Sprague-Dawley rats (60 per sex and dose) were exposed to D-003 on 5 d/w for 24 months via gavage in doses of 0, 50, 500 and 1500 mg/kg bw/d . No treatment related effect was observable
Malignant and benign tumours occured less frequently in treated groups compared to controls, as shown in the following table. The reduction of incidence in treated females for malignant tumours was significant with respect to control values. The most prominent non-neoplastic lesion was glomerulonephritis, which occured in 9, 1, 5 and 7 males of the control, 50, 500 and 1500 mg/kg/day groups, respectively, and in 6 control females and 1 female treated with 500 mg/kg/day. Several inflammations were observed at low frequencies, and no differences were evident between control and treated animals.
Male animals with malignant tumours
Male animals with benign tumours
Female animals with malignant tumours
Female animals with benign tumours
Controls (n=60 per sex)
50 (n=60 per sex)
500 (n=60 per sex)
1500 (n=60 per sex)
The test substance (D-003) was administered to Sprague-Dawley rats (60 per sex and dose) by oral gavage in daily doses of 0, 50, 500 and 1500 mg/kg bw/day, 5 days per week, for 24 months. No treatment related effects were observed with respect to survival, body weight gain, food consumption, clinical symptoms, blood biochemistry (except serum cholesterol reduction, an effect specific for D-003), organ weights, and non-neoplastic or carcinogenic histopathological effects.
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