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EC number: 200-826-3 | CAS number: 74-97-5
Weight of evidence: Bacterial reverse mutation assays (Ames tests), with and without metabolic activation, and a Chromosome aberration test have been conducted for bromochloromethane. Results of these tests have been considered positive evidence of mutagenicity. Bromochloromethane was mutagenic in Salmonella typhimurium and E.coli tests and induced sister cromatid exchange and chromosome aberrations in Chinese hamster cells in vitro. Although these in vitro studies are not sufficient for classification may offer supporting information in the event of in vivo mutagenicity data.
Only in vitro studies are available for bromochloromethane. There are no studies of exposed humans and no genotoxicity tests in vivo. Thus, there are no data available that would justify classification for germ cell mutagenicity according to CLP criteria.
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