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EC number: 700-535-6
CAS number: 1190931-34-0
The potential of the test item, DIOX alcohol, to induce and elicit
delayed dermal sensitisation was assessed by a guinea pig model using
the methods of Buehler. The concentrations of the test item used in the
main study were determined on the basis of the results obtained from a
preliminary screening test carried out on DIOX alcohol (maximum
concentration tested: 100%). The main sensitisation test was undertaken
using a test group of 20 animals and a control group of 10 animals. In
an attempt to induce sensitisation, test animals were treated by topical
application of the undiluted test item. This was repeated at weekly
intervals for a total of 3 weeks. Animals of the control group were
treated in the same manner but the vehicle alone (sterile water) was
used in place of the test item. Two weeks after the third and final
induction exposure, animals of the test and control groups were
challenged by topical application of both the vehicle alone (sterile
water) and the test item at the same concentration used for induction.
At challenge no response was observed to the test item, at the selected
concentration, in either test or control group animals. No reaction was
observed to the vehicle alone (sterile water). These results indicate
that the test item does not elicit a sensitisation response in the
guinea pig, being there no evidence of response at challenge following a
period of induction exposure to the test item, DIOX alcohol.
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