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EC number: - | CAS number: -
Undiluted ethoxylated lauryl phosphate (CAS 39464 -66 -9) was applied to the closely clipped, intact skin of New-Zealand White rabbits, at the doses of 2000 (one female), 3160 (one male), 5010 (one female) and 7940 (one male) mg/kg bw.
The treated skin areas were covered with plastic strips. Observations were made for mortality or signs of toxicity and the viscera of the test animals were examined macroscopically. Surviving animals were sacrificed 14 days after dosing.
No mortality occurred in Female #1 and Male #2 given 2000 and 3160 mg/kg bw, respectively. Female #3 given 5010 mg/kg bw died 3 days after dosing. Male #4 given 7940 mg/kg bw died 2 days after dosing. Clinical signs included reduced appetite and activity (2 to 4 days in surviving animals), increasing weakness and collapse. Body weights of Female #1 and Male #2 were unchanged or decreased by 0.1 kg, respectively, 5 days after dosing. At necropsy, lung and liver hyperemia, slightly enlarged gall bladder and gastrointestinal inflammation was noted in animals found dead. The viscera appeared normal in surviving animals sacrificed 14 days after dosing.
The minimal lethal dose in 2 out of 4 tested rabbits was higher than 3160 mg/kg bw but lower or equal to 5010 mg/kg bw. The substance should therefore be considered as Acute Tox. 5, H313 (May be harmful in contact with skin) according to the UN-GHS classification criteria, but is not classified for acute dermal toxicity according to DSD or CLP criteria.
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