Registration Dossier
Registration Dossier
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EC number: 400-820-2 | CAS number: 84268-33-7
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
- Principles of method if other than guideline:
- Test procedure:
OBJECTIVE:
To investigate the effects of CG 20-571 and its metabolite
CG 20-568 on selected biochemical and morphological
parameters of the male rat liver.
Species/strain: Rat (RAI)
NUMBER OF ANIMALS:
Substance Dose (mg/kg) Number of animals
CG 20-571 10 5
50 5
200 5
CG 20-568 10 5
50 5
200 5
Controls: 10 animals per dose level
Route: Oral (Gavage)
Frequency: Daily for 14 days
VEHICLE: 0.5% carboxymethylcellulose
Test material
- Reference substance name:
- -
- EC Number:
- 400-820-2
- EC Name:
- -
- Cas Number:
- 84268-33-7
- Molecular formula:
- C20H23N3O3
- IUPAC Name:
- methyl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate
Constituent 1
Results and discussion
- Details on results:
- Signs of toxicity:
No deaths and no signs of toxicity. Reduced body weight gain
was noted in animals treated with 50 or 200 mg/kg CG 20-568.
Effects on liver:
Dose-related increase in absolute liver weight at 10 mg/kg
and above for both substances (80-90% above controls at
highets dose).
Ultrastructural examination of animals treated with 200
mg/kg revealed a striking proliferation of peroxisomes,
particularly with CG 20-568. A marginal proliferation of
smooth endoplasmic reticulum was noted with CG 20-568.
There was a dose-dependent and statistically high
significant increase in peroxisomal beta-oxidation at 10
mg/kg and above for both substances. Increased cytochrome
P-452 and decreased activity of UDP-glucuronosyltransferase
and glutathione S-transferase were also noted with both
substances.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
