Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-906-0 | CAS number: 89-41-8
3-Nitro-4-methoxybenzoesäure was tested for mutagenicity with the strains TA 100, TA 1535, TA 1537, TA 1538, TA 98 of Salmonella typhimurium and Escherichia coli WP2uvrA. The mutagenicity studies were conducted in the absence and in the presence of a metabolizing system derived from rat liver homogenate. A dose range of 8 different doses from 0.16 µg/plate to 5000 µg/plate was used. Control plates (solvent control) without test item showed that the number of spontaneous revertant colonies was similiar to that described in the literature. All the positive control compounds gave the expected increase in the number of revertant colonies. Toxicity: The test compound proved to be very toxic to the bacterial strains at 100 µg/plate. 5000 microgram/plate was chosen as top dose level for the mutagenicity study. Mutagenicity: In the absence of the metabolic activation system, the test compound gave a dose dependent increase in the number of revertant colonies with the bacterial strains Salmonella TA 98, TA 100, TA 1537, and E. coli WP2uvrA. Also in the presence of metabolic activation, treatment of the cells with 3-Nitro-4-methoxybenzoesäure results in relevant increases in the number of revertant colonies with the Salmonella strains TA 98, TA 100, TA 1537, and E. coli WP2uvrA. Summarizing, it can be stated that 3-Nitro-4-methoxybenzoesäure is mutagenic with and without exogenous metabolic activation in this bacterial reverse mutation assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again