Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 400-100-8 | CAS number: 84057-97-6 BLEU N-RM 2114; BLEU NYLOSAN N-BLN; BLUE N-RM 2114; NYLOSAN BLAU N-BLN; NYLOSAN BLEU N-BLN; NYLOSAN BLUE N-BLN
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only data summary seen from SNIF docs
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- No data from SNIF file
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- 3 animals
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- Applied to skin as moistened in water. 0.5g per animal
- Observation period:
- 72 hours
- Number of animals:
- 3
- Remarks on result:
- other: other: not classified
- Conclusions:
- Data obtained through ECHA Inquiry under the 12 year rule.
- Executive summary:
Data obtained through ECHA Inquiry under the 12 year rule.
Reference
Comments: 4105 SKIN IRR RESULT: No dermal irritation. Localised light blue colouration after removing dressing, persisting for up to 72 hours. The substance is not a skin irritant. 22
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only data summary seen from SNIF docs
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Remarks on result:
- other: Other: not classified
- Conclusions:
- Data obtained through ECHA Inquiry under the 12 year rule.
- Executive summary:
Data obtained through ECHA Inquiry under the 12 year rule.
Reference
4106 EYE IRR RESULT: Clear irritation noted immediately on application due, in part, to the physical state of the material. Moderate conjunctival and corneal irritation persisted for up to 48 hours post-dose, but cleared by 72 hours. The substance is not classified as an eye irritant.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Not classified as skin or eye irritant on basis of animal testing for NONS notification.
Discolouration is caused they the test material.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
