1-(2,6-dimethylphenoxy)acetone

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13.12.1999 - 13.01.2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was conducted by a well experienced research laboratory and in accordance with several internationally acknowledged guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

The incubated solutions were filtered instead of centrifugated. The reequilibration temperature was 20 °C ± 2 °C instead of 20 °C ± 0.5 °C.

Test guideline 2

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

yes

Remarks:

The incubated solutions were filtered instead of centrifugated. The reequilibration temperature was 20 °C ± 2 °C instead of 20 °C ± 0.5 °C.

Test guideline 3

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

The incubated solutions were filtered instead of centrifugated. The reequilibration temperature was 20 °C ± 2 °C instead of 20 °C ± 0.5 °C.

GLP compliance:

not specified

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

1-(2,6-dimethylphenoxy)acetone

EC Number:

258-292-2

EC Name:

1-(2,6-dimethylphenoxy)acetone

Cas Number:

53012-41-2

Molecular formula:

C11H14O2

IUPAC Name:

1-(2,6-dimethylphenoxy)propan-2-one

Results and discussion

Water solubility

Water solubility:

2.15 g/L

Temp.:

20 °C

Remarks on result:

other: standard deviation: ± 0.04 g/L

Details on results:

Result of the Preliminary Test: The water solubility of 2,6-DMPA was estimated to be higher than 1 g/L by visual judgement

Any other information on results incl. tables

Results for Determination of the Water Solubility of 2,6-DMPA*

Sample No.	Shaking Time at 30 °C [h]	Initial Weight of 2,6-DMPA [g]	Initial Water Volume [mL]	measured pH after Incubation	Concentration 2,6-DMPA found [mg/L]
1	72	1.0112	20	4.7	2130
2	72	1.0047	20	4.8	2150
3	48	1.002	20	4.7	2110
4	48	1.0047	20	4.3	2130
5	24	1.0119	20	4.4	2170
6	24	1.0658	20	4.3	2230

*The tabulated values represent rounded results, which were obtained by calculation using the exact raw data.

Quantification Limit was calculated tobe 480 mg test item/L (according to DIN 32645)

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of 2,6-DMPA was determined to be 2.15 g/L ± 0.04 g/L standard deviation at 20 °C ± 2 °C using the flask method for the
performance of the main test.