Inositol phosphates

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From April 06, 2009 to April 20, 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The study was conducted according to Method A.4 (Vapour Pressure) of Commission Regulation (EC) No 440/2008 of 30 May 2008. GLP compliance is claimed through compliance with UK Good Laboratory Practice standards [Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)].

Justification for data waiving:

other:

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

isoteniscope

Test material

Test material information

Constituent 1

Reference substance name:

Inositol phosphates

EC Number:

700-206-7

Molecular formula:

As this substance is a UVCB substance and consists varying degree of components, a single molecular formula is not applicable

IUPAC Name:

Inositol phosphates

Constituent 2

Reference substance name:

Synthetic inositol phosphates

IUPAC Name:

Synthetic inositol phosphates

Details on test material:

- Name of test material (as cited in study report): Synthetic Inositol phosphates
- Physical state: Amber coloured liquid
- Lot/batch No.: 95816206JH-012
- Storage condition of test material: Room temperature in the dark

Results and discussion

Vapour pressure

Temp.:

25 °C

Vapour pressure:

2 000 Pa

Transition / decomposition

Transition / decomposition:

no

Remarks:

test material did not change in appearance under the set of conditions used in the experiment.

Any other information on results incl. tables

Table 1: Data for vapour pressure and temperature in Run 1

Temperature (°C)	Vapour pressure (Pa)	Temperature (K)	Reciprocal temperature (1/K)	Log10Vp
91.2	52795.66	364.35	0.002744614	4.722598206
90.4	51195.79	363.55	0.002750653	4.709234245
89.6	49595.92	362.75	0.00275672	4.69544596
88.8	48129.38	361.95	0.002762813	4.682410222
88.2	46529.51	361.35	0.0027674	4.667728447
87.4	45329.61	360.55	0.00277354	4.656381937
86.6	43863.06	359.75	0.002779708	4.642098918
86	42663.16	359.15	0.002784352	4.630052998
84.8	40796.64	357.95	0.002793686	4.610624447
84	39463.42	357.15	0.002799944	4.596194731
83.1	37730.23	356.25	0.002807018	4.576689456
82.3	36530.33	355.45	0.002813335	4.562653583
81.6	35197.11	354.75	0.002818887	4.546506947
80.5	33863.88	353.65	0.002827654	4.529736737
79.6	32530.66	352.75	0.002834869	4.512292846
78.7	31197.43	351.85	0.00284212	4.494118878
77.7	29864.21	350.85	0.002850221	4.475151038
76.7	28530.99	349.85	0.002858368	4.455316793
75.9	27464.41	349.05	0.002864919	4.438770241

Graph of Log₁₀Vp vs reciprocal temperature (1/K) – see attached document titled ‘Run 1 - Graph Log₁₀Vp vs K^-1'

Table 2: Data for vapour pressure and temperature in Run 2

Temperature (°C)	Vapour pressure (Pa)	Temperature (K)	Reciprocal temperature (1/K)	Log10Vp
87.1	46662.83	360.25	0.00277585	4.6689711
86.3	45062.96	359.45	0.002782028	4.6538197
85.5	43463.09	358.65	0.002788234	4.6381206
84.6	41996.55	357.75	0.002795248	4.6232136
83.6	40530	356.75	0.002803083	4.6077766
82.9	39196.78	356.05	0.002808594	4.5932504
82	37863.55	355.15	0.002815712	4.5782214
81.2	36796.97	354.35	0.002822069	4.5658121
80.2	35463.75	353.35	0.002830055	4.5497847
79.2	34130.53	352.35	0.002838087	4.533143
78.3	32797.3	351.45	0.002845355	4.5158381
77.5	31464.08	350.65	0.002851847	4.497815
76.4	30130.86	349.55	0.002860821	4.4790115
75.5	28797.63	348.65	0.002868206	4.4593568
74.4	27731.05	347.55	0.002877284	4.4429664
73.5	26397.83	346.65	0.002884754	4.4215682

Graph of Log₁₀Vp vs reciprocal temperature (1/K) – see attached document titled ‘Run 2 - Graph Log₁₀Vp vs K^-1'

Table 3: Data for vapour pressure and temperature in Run 3

Temperature (°C)	Vapour pressure (Pa)	Temperature (K)	Reciprocal temperature (1/K)	Log10Vp
88.1	46796.15	361.25	0.002768166	4.670210137
87.3	45329.61	360.45	0.00277431	4.656381937
85.4	42129.87	358.55	0.002789011	4.624590103
84.3	40530	357.45	0.002797594	4.607776604
83.3	38663.49	356.45	0.002805443	4.587301018
82.3	36796.97	355.45	0.002813335	4.565812102
81.5	35463.75	354.65	0.002819681	4.549784657
80.5	34130.53	353.65	0.002827654	4.533142985
79.6	32797.3	352.75	0.002834869	4.515838127
78.7	31464.08	351.85	0.00284212	4.497815023
77.7	30130.86	350.85	0.002850221	4.479011459
77	28797.63	350.15	0.002855919	4.459356771
75.8	27464.41	348.95	0.00286574	4.438770241
75.2	26664.47	348.35	0.002870676	4.425933016

Graph of Log₁₀Vp vs reciprocal temperature (1/K) – see attached document titled ‘Run 3 - Graph Log₁₀Vp vs K^-1’

Table 4: Summary of results

Run	Log10Vp (at 25 °C)
1	3.288
2	3.378
3	3.268
Mean	3.311
Vapour Pressure = 2.0 X 10^3Pa

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the test material was determined to be 2000 Pa at 25°C.

Executive summary:

A study was conducted to determine the vapour pressure of synthetic inositol phosphates using an isoteniscope system according to the EU Method A.4 (Vapour Pressure).

The vapour pressure of the test material was measured over a range of temperatures [94-71°C (run 1), 91 -73°C (run 2) and 90-70°C (run 3)], to enable extrapolation to 298.15 K.

The vapour pressure of the test material was determined to be 2000 Pa at 25 °C.