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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: There is no reference to GLP or guidelines, but the methods and results are well documented. This study is not comparable to any guideline.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1997

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
acute toxicity: inhalation

Test material

Constituent 1
Chemical structure
Reference substance name:
Magnesium oxide
EC Number:
215-171-9
EC Name:
Magnesium oxide
Cas Number:
1309-48-4
Molecular formula:
MgO
IUPAC Name:
Magnesium oxide

Results and discussion

Applicant's summary and conclusion

Conclusions:
There were no adverse effects noted in humans exposed to magnesium oxide particles by inhalation.
Executive summary:

Kuschner et al:

The goal of this study was to characterise human pulmonary responses to controlled experimental high-dose exposure to fine and ultrafine magnesium oxide particles. Six normal volunteers inhaled purified magnesium oxide particles. Four males and two females were examined and they were both smokers and non smokers. Measurements were obtained from the same six subjects without prior magnesium exposure for comparison. Pulmonary inflammatory cell and cytokine responses were measured 20 hours postexposure by analysis of bronchoalveolar lavage fluid. Peripheral blood neutrophil and pulmonary function 18 hours postexposure were also measured. The exposure levels tested ranged from 5.8 to 230 mg/m3 with a median magnesium concentration of 133 mg/m3, and exposure time was varied between 15 and 45 minutes.

None of the subjects documented a fever or any symptoms associated with metal fume fever. There was no overall postexposure fall in pulmonary function. Slight increases in total lung capacity and the diffusing capacity for CO were not statistically significant. There were no statistically significant differences in concentrations of BAL neutrophils, macrophages, lymphocytes, protein or increases in any of the proinflammatory cytokines studied between postexposure and paired control values. In conclusion magnesium oxide did not show any toxicity towards the six subjects tested in this experiment.

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